Everything about ceesdekker.net
Everything about ceesdekker.net
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‘Of course, that's about suitable. I look for a Actual physical understanding of biological units within a base-up way. I do think you can distinguish 3 strains of study in my team for the time being. The primary fears chromosome structure: How would you receive a metre-lengthy DNA polymer folded and organised in this type of microscopic mobile? Now we have produced visualisation approaches that allow us to study how, one example is, SMC proteins loop DNA (online video on Youtube) to be able to build up chromosomes.
It was only inside the nineties even though, when nanotechnology experienced Sophisticated to a degree in which solitary molecules could possibly be manipulated, that the 1st experimental devices started to appear.
[Laughs] ‘It absolutely was definitely a great danger! At the time, I was nicely aware that it could go wrong Which I could come to be significantly less prosperous, but I just overlooked that. Curiosity has generally been my strongest driving pressure. And luckily all of it worked out.’
Our function was rapidly followed up by Other individuals, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 revealed their results on transistors comprised of one- and multi-walled carbon nanotubes in Applied Physics Letters.
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initially ever study of your dynamics DNA supercoils and the discovery of supercoil hopping
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is the fact that these factors collectively make up a dwelling program. The trick of explained life, I feel, lies within the interactions, the interaction of those molecules. The large question with regards to the origin of existence continues to be unanswered. How did we at any time evolve from straightforward molecules in the incredibly advanced units we see nowadays? We do not know. I need to work on These types of massive, open up concerns.’
2011, initially in vitro measurements of transportation across just one biomimetic nuclear pore sophisticated; improvement of multiplexed magnetic cees dekker tweezers for kilo-molecule experiments; and resolved the system of homology recognition in DNA homologous recombination
2003, shown the 1st biosensors designed away from a carbon nanotube; settled the structure and mechanism of DNA maintenance proteins; and discovery of a different procedure for fabricating reliable-state nanopores for DNA translocation
Bulk-surface area coupling identifies the mechanistic link amongst Min-protein styles in vivo As well as in vitro
Testing pseudotopological and nontopological types for SMC-pushed DNA loop extrusion against roadblock-traversal experiments
Lots of new phenomena have been found, and he and his investigate group established a number one place During this discipline of study. Dekker and his exploration group learned new physics of nanotubes along with explored the feasibility of molecular electronics. In 1998, they were the 1st to construct a transistor based upon just one nanotube molecule.
2005, discovery of your mechanism of DNA uncoiling by topoisomerase enzymes; discovery of extensive-assortment conformational variations in Mre11/DNA mend complexes; and 1st force measurements on the DNA molecule inside of a nanopore
Ultimately, I will briefly sketch a number of our Strategies to explore the developing of synthetic cells, particularly our very first methods to ascertain artificial cell division.